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Proguanil Hydrochloride BP

Proguanil Hydrochloride BP
Proguanil Hydrochloride BP
Product Code : 07
Product Description

Name of Product: PROGUANIL HYDROCHLORIDE                                       

       Chloroguanide Hydrochloride

 Proguanil Hydrochloride is 1-(4-chlorophenyl)-5- isopropylbiguanide hydrochloride.

 Formula: C11H16ClN5,HCl                              Category: Antimalarial.         

Mol. Wt.: 290.19

Dose: Suppressive, 100 to 300 mg daily.

Sr. No.

 

 

 

Analysis

 

 

 

Specification

 

 

 

1

 

 

 

Description

 

 

 

White, crystalline powder; odourless.

 

 

 

2

 

 

 

Solubility

 

 

 

Soluble in ethanol (95%); slightly soluble in water; practically insoluble in chloroform and in ether.

 

 

 

3

 

 

 

Identification:

 

A:

 

 

 

D:

 

 

 

 

 

 

 

 

 

 

 

By  infra-red absorption spectrum

 

 

 

Gives the reactions of chlorides,

 

 

 

 

 

 

 

 

 

4

 

 

 

Acidity or Alkalinity

 

 

 

To 35 ml of water maintained at 60o to 65o add 0.2 ml of methyl red solution, neutralise with 0.01M sodium hydroxide or 0.01M hydrochloric acid, add 0.4 g of the substance being examined and stir until dissolved. The resulting solution is not acidic and requires for neutralisation not more than 0.2 ml of 0.01M hydrochloric acid.

 

 

 

5

 

 

 

Sulphated Ash

 

 

 

Not more than 0.1%

 

 

 

6

 

 

 

Loss on Drying

 

 

 

Not more than 0.5%, determined on 1 g by drying in an oven at 105o

 

 

 

7

 

 

 

Assay

 

 

 

Proguanil Hydrochloride contains not less than 99.0 per cent and not more than 101.0 per cent of C11H16ClN5,HCl, calculated with reference to the dried substance.

 


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