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Name of Product: PROGUANIL HYDROCHLORIDE Chloroguanide Hydrochloride Proguanil Hydrochloride is 1-(4-chlorophenyl)-5- isopropylbiguanide hydrochloride. Formula: C11H16ClN5,HCl Category: Antimalarial. Mol. Wt.: 290.19 Dose: Suppressive, 100 to 300 mg daily.
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Sr. No.
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Analysis
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Specification
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1
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Description
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White, crystalline powder; odourless.
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2
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Solubility
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Soluble in ethanol (95%); slightly soluble in water; practically insoluble in chloroform and in ether.
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3
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Identification:
A:
D:
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By infra-red absorption spectrum
Gives the reactions of chlorides,
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4
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Acidity or Alkalinity
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To 35 ml of water maintained at 60o to 65o add 0.2 ml of methyl red solution, neutralise with 0.01M sodium hydroxide or 0.01M hydrochloric acid, add 0.4 g of the substance being examined and stir until dissolved. The resulting solution is not acidic and requires for neutralisation not more than 0.2 ml of 0.01M hydrochloric acid.
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5
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Sulphated Ash
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Not more than 0.1%
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6
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Loss on Drying
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Not more than 0.5%, determined on 1 g by drying in an oven at 105o
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7
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Assay
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Proguanil Hydrochloride contains not less than 99.0 per cent and not more than 101.0 per cent of C11H16ClN5,HCl, calculated with reference to the dried substance.
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