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Proguanil Hydrochloride IP chemicals

Proguanil Hydrochloride IP chemicals
Proguanil Hydrochloride IP chemicals
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Product Code : 12
Brand Name : PALAM
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Product Description

We have earned our name as a renowned organization engaged in offering Proguanil Hydrochloride IP Chemicals. These are biguanide compound, metabolize in the body to form cycloguanil, an anti-malaria agent. To comply with set safety norms, we use finest quality compounds, sourced from trusted vendors. These chemicals are active against several protozoal species and are used in combination with atovaquone and chloroquine for the prevention and therapy of malaria. Proguanil Hydrochloride IP Chemicals inhibit the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite. These chemicals are soluble in water; practically insoluble in chloroform and in ether.

 

 

Proguanil Hydrochloride IP

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Chloroguanide Hydrochloride

Proguanil Hydrochloride is 1-(4-chlorophyll)-5- isopropyl biguanide hydrochloride.

Formula: C11H16ClN5,HCl Category: Antimalarial.

Mol. Wt.: 290.19

Dose: Suppressive, 100 to 300 mg daily.



Sr. No.




Analysis




Specification




1




Description




White, crystalline powder; odorless.




2




Solubility




Soluble in ethanol (95%); slightly soluble in water; practically insoluble in chloroform and in ether.




3




Identification:


A:



D:











By infra-red absorption spectrum



Gives the reactions of chlorides,








4




Acidity or Alkalinity




To 35 ml of water maintained at 60o to 65o add 0.2 ml of methyl red solution, neutralize with 0.01M sodium hydroxide or 0.01M hydrochloric acid, add 0.4 g of the substance being examined and stir until dissolved. The resulting solution is not acidic and requires for neutralization not more than 0.2 ml of 0.01M hydrochloric acid.




5




Sulphates Ash




Not more than 0.1%




6




Loss on Drying




Not more than 0.5%, determined on 1 g by drying in an oven at 105o




7




Assay




Proguanil Hydrochloride contains not less than 99.0 per cent and not more than 101.0 per cent of C11H16ClN5,HCl, calculated with reference to the dried substance.













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