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Dicycloverine HCL BP
We are a leading company specializing in the business of offering our clients Dicycloverine HCL BP. It is a muscarinic antagonist used as an antispasmodic and in urinary incontinence. Our skilled manpower uses best quality compounds to process this medication. It has little effect on glandular secretion or the cardiovascular system. It does have some local anesthetic properties and is used in gastrointestinal, biliary, and urinary tract spasms. Dicycloverine HCL BP reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle.
Dicycloverine HCL BP is 2-diethylaminoethyl- bicyclohexyl-1-carboxylate hydrochloride
Formula: C19H35NO2, HCl
Mol. Wt.: 345.95
Dose: 30 to 60 mg daily, in divided doses. If used as an oral solution and the solution is required to be diluted, the diluted solution should be freshly prepared.
||White or almost white, crystalline powder; odourless or almost odourless.
||Freely soluble in ethanol (95%) and in chloroform; soluble in water; practically insoluble in ether.
||By infra-red absorption spectrum
||To 3 ml of a 0.1% w/v solution of sodium dodecyl sulphate, add 5 ml of chloroform and 0.05 ml of a 0.25% w/v solution of methylene blue, mix gently and allow to separate; the chloroform layer is blue. Add 20 mg of the substance being examined dissolved in 2 ml of water, mix gently and allow to separate; the aqueous layer is blue and the chloroform layer is colourless.
|C: Chloride Test||Dissolve 10 mg in 5 ml of water and add 0.2 ml of 2M nitric acid and 0.5 ml of silver nitrate solution; a white precipitate is produced.
|D: Melts||Between 172o and 174o.
||Any secondary spot in the chromatogram obtained with solution (1) is not more intense than the spot in the chromatogram obtained with solution (2).
||Not more than 0.1%.
|Loss on Drying
||Not more than 1.0%, determined on 1 g by drying in an oven at 105o
||Dicycloverine HCL BP contains not less than 99.0 per cent and not more than 101.0 per cent of C19H35NO2,HCl, calculated with reference to the dried substance.|